Corticosteroids may reduce mortality in patients with sepsis
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Corticosteroids may reduce mortality in patients with sepsis

Findings suggest that corticosteroids use is associated with reduced 28-day mortality compared with placebo use or standard supportive care.


In this systematic review and meta-analysis of 37 randomized clinical trials that included 9564 patients with sepsis, administration of corticosteroids was associated with reduced 28-day mortality. Corticosteroids were also significantly associated with increased shock reversal at day 7 and vasopressor-free days and with decreased intensive care unit length of stay, the Sequential Organ Failure Assessment score at day 7, and time to resolution of shock.


The findings suggest that administration of corticosteroid treatment in patients with sepsis is associated with significant improvement in health care outcomes and thus with reduced 28-day mortality.


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