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5 Facts you should know about
Progressive multifocal leukoencephalo
pathy (PML)
1
PML is a demyelinating disease, in which the myelin sheath covering the axons of nerve cells is gradually destroyed
2
It is caused by a virus called JC virus (JCV), named after the initials of the patient in whom it was first discovered
3
PML has a mortality rate of 30%–50% in the first few months, and those who survive can be left with varying degrees of neurological disabilities
4
The most common area of involvement is the cortical white matter of frontal and parieto-occipital lobes
5
No drugs effectively inhibit or cure the viral infection without toxicity
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