Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.
Age of Onset
Autosomal dominant ?A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease
Autosomal recessive ?Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype
X-linked dominant ?X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
X-linked recessive ?Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder
Mitochondrial or multigenic ?Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.
Multigenic or multifactor ?Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.
Other Names (AKA)
Congenital and Genetic Diseases; Endocrine Diseases; Male Reproductive Diseases;
Adrenomyeloneuropathy (AMN) is an
- Difficulty walking
- Changes in gait (style of walking)
- Progressive stiffness and weakness of the legs
- Speech difficulties
- Adrenal insufficiency
- Sexual dysfunction and/or
- Problems with bladder control
- Weight loss
In addition to the symptoms above, people with AMN with cerebral involvement may develop behavioral abnormalities, vision loss, hearing problems and/or
This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.
|Medical Terms||Other Names||
|Percent of people who have these symptoms is not available through HPO|
|Abnormality of the cerebral white matter||0002500|
|Attention deficit hyperactivity disorder||
Attention deficit disorder
Attention deficit-hyperactivity disorder
Childhood attention deficit/hyperactivity disorder
[ more ]
Loss of bowel control
[ more ]
|Elevated circulating long chain fatty acid concentration||0003455|
[ more ]
|Hyperpigmentation of the skin||
Patchy darkened skin
Decreased activity of gonads
|Impaired vibration sensation at ankles||
Decreased vibration sense at ankles
Decreased vibration sense in feet
[ more ]
Difficulty getting a full erection
Difficulty getting an erection
[ more ]
Difficulties in coordination
Incoordination of limb movements
[ more ]
|Loss of speech||0002371|
|Lower limb muscle weakness||
Lower extremity weakness
Lower limb weakness
Muscle weakness in lower limbs
[ more ]
Ongoing loss of nerve cells
Partial paralysis of legs
Peripheral nerve disease
|Primary adrenal insufficiency||0008207|
Worsens with time
Instability or lack of coordination of central trunk muscles
|Urinary bladder sphincter dysfunction||0002839|
Loss of bladder control
Loss of vision
[ more ]
- The Genetic Testing Registry (GTR) provides information about the genetic tests for this condition. The intended audience for the GTR is health care providers and researchers. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.
Related diseases are conditions that have similar signs and symptoms. A health care provider may consider these conditions in the table below when making a diagnosis. Please note that the table may not include all the possible conditions related to this disease.
Conditions with similar signs and symptoms from Orphanet
Differential diagnoses include hereditary spastic paraplegias, primary lateral sclerosis, cerebrotendinous xanthomatosis, metachromatic leukodystrophy and Krabbe disease (see these terms) as well as difficiencies in vitamin B12, folic acid or copper. AI symptoms may ressemble Addison Disease (see this term).
Visit the Orphanet disease page for more information.
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
Association Européenne contre les Leucodystrophies (ELA)
European Leukodystrophy Association
2, rue Mi-les-Vignes
54521 Laxou Cedex, France
Telephone: 333 83 30 93 34
Fax: 333 83 30 00 68
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
- MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
- Genetics Home Reference (GHR) contains information on Adrenomyeloneuropathy. This website is maintained by the National Library of Medicine.
- The National Organization for Rare Disorders (NORD) has a report for patients and families about this condition. NORD is a patient advocacy organization for individuals with rare diseases and the organizations that serve them.
- The United Leukodystrophy Foundation has developed an information page on Adrenomyeloneuropathy. Click on the link above to view this information page.
- GeneReviews provides current, expert-authored, peer-reviewed, full-text articles describing the application of genetic testing to the diagnosis, management, and genetic counseling of patients with specific inherited conditions.
- Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Adrenomyeloneuropathy. Click on the link to view a sample search on this topic.
- Adrenomyeloneuropathy (AMN). United Leukodystrophy Foundation. https://ulf.org/adrenomyeloneuropathy-amn.
- Alan K Percy, MD; Ronald JA Wanders, PhD. Adrenoleukodystrophy. UpToDate. February 2015;
- X-linked adrenoleukodystrophy. Genetics Home Reference. July 2013; https://ghr.nlm.nih.gov/condition/x-linked-adrenoleukodystrophy.
- Steven J Steinberg, PhD, Ann B Moser, BA, and Gerald V Raymond, MD. X-Linked Adrenoleukodystrophy. GeneReviews. April 2012; https://www.ncbi.nlm.nih.gov/books/NBK1315/.