Chronic graft versus host disease
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.
Age of Onset
Autosomal dominant ?A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease
Autosomal recessive ?Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype
X-linked dominant ?X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
X-linked recessive ?Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder
Mitochondrial or multigenic ?Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.
Multigenic or multifactor ?Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.
Other Names (AKA)
Immune System Diseases; RDCRN
Chronic graft versus host disease (GVHD) is a complication that can occur after a
The medication(s) listed below have been approved by the Food and Drug Administration (FDA) as orphan products for treatment of this condition. Learn more orphan products.
- Ibrutinib(Brand name: Imbruvica) Manufactured by Pharmacyclics, LLC
FDA-approved indication: Treatment of adult patients with chronic graft versus host disease (cGVHD).
National Library of Medicine Drug Information Portal
Medline Plus Health Information
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
- MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
- Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Chronic graft versus host disease. Click on the link to view a sample search on this topic.
- Graft-versus-host disease. MedlinePlus. June 2012; https://www.nlm.nih.gov/medlineplus/ency/article/001309.htm. Accessed 2/21/2013.
- Chronic Graft-versus-host disease. Chronic Graft Versus Host Disease Consortium. https://rarediseasesnetwork.epi.usf.edu/cGVHD/chronic/. Accessed 2/21/2013.
- Mandanas RA. Graft Versus Host Disease. Medscape Reference. December 2012; https://emedicine.medscape.com/article/429037-overview. Accessed 2/21/2013.