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Disease Profile

De Quervain’s disease

Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.


US Estimated

Europe Estimated

Age of onset





Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease.


Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype.


dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.


recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.


Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.


Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.


Not applicable


Other names (AKA)

De Quervains tenosynovitis; De Quervain's syndrome; De Quervain's tendonitis;


De Quervain's disease is a painful wrist condition that affects the tendons on the thumb side of the wrist (the radial side).[1] Symptoms may include pain or tenderness when moving the thumb, turning the wrist, grasping something, or making a fist.[1][2] Pain may radiate to the thumb or forearm. Some people have swelling on the radial side of the wrist or difficulty holding objects.[3]

The cause of de Quervain's disease is poorly understood.[3] Symptoms result from entrapment (compression) of the tendons in the affected area.[2] Two tendons in the wrist and lower thumb normally glide smoothly through a tunnel connecting them to the thumb. If the area around the tendons becomes irritated, swelling may restrict their movement. The condition is often attributed to occupational or repetitive activities involving extending the thumb.[3] It is most common among women between the ages of 30 and 50, including women who have recently had a baby or others who repetitively lift infants.[3][2] It may also develop in people who have sustained direct trauma to the affected area.[2]

Treatment for de Quervain's disease may first involve splinting of the thumb and wrist, or corticosteroid injections to reduce inflammation. If injection therapy fails, surgery can relieve the entrapment.[2]


Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.

Organizations Supporting this Disease

    Learn more

    These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.

    Where to Start

    • Mayo Clinic has an information page on De Quervain's disease.
    • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
    • The The Cleveland Clinic Web site has an information page on De Quervain's disease. Click on the Cleveland Clinic link to view this page.

      In-Depth Information

      • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
      • The Merck Manual for health care professionals provides information on De Quervain's disease.


        1. De Quervain's tenosynovitis. Mayo Clinic. June 13, 2015; https://www.mayoclinic.org/diseases-conditions/de-quervains-tenosynovitis/basics/definition/con-20027238.
        2. Meals RA. De Quervain Tenosynovitis. Medscape Reference. July 7, 2016; https://emedicine.medscape.com/article/1243387-overview.
        3. Aggarwal R, Ring D. de Quervain tendinopathy. UpToDate. Waltham, MA: UpToDate; June 10, 2015; https://www.uptodate.com/contents/de-quervain-tendinopathy.
        4. Foye PM. Physical Medicine and Rehabilitation for De Quervain Tenosynovitis. Medscape Reference. April 27, 2016; https://emedicine.medscape.com/article/327453-overview#a6.
        5. Ilyas AM, Ast M, Schaffer AA, Thoder J. De quervain tenosynovitis of the wrist. J Am Acad Orthop Surg. December, 2007; 15(12):757-764. https://www.ncbi.nlm.nih.gov/pubmed/18063716.