Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.
Age of Onset
Autosomal dominant ?A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease
Autosomal recessive ?Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype
X-linked dominant ?X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
X-linked recessive ?Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder
Mitochondrial or multigenic ?Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.
Multigenic or multifactor ?Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.
Other Names (AKA)
Kidney and Urinary Diseases; Nervous System Diseases; Skin Diseases
Dermatomyositis is an autoimmune condition that causes skin changes and muscle weakness. Symptoms can include a red skin rash around the eyelids, red bumps around the joints, and muscle weakness in the arms and legs. Dermatomyositis is most common in adults between ages 40 and 60, or in children between ages 5 and 15. Muscle weakness gets worse over time and can lead to stiff joints and muscle wasting. The cause for dermatomyositis is unknown. Diagnosis is made through a clinical exam and microscopic examination of a piece of skin and muscle. Treatment is focused on managing the symptoms. Options include different medications,
- A reddish-purple rash around the eyelids
- Red or violet bumps that form on the outside joints of the hand (Gottron papules)
- Red or violet bumps on the knees and elbows
- Discolored skin on shoulders, neck, upper back (shawl sign)
- Muscle weakness starting in the arms and/or legs
- Joint pain
The symptoms of dermatomyositis may appear suddenly or develop gradually. The first symptom of dermatomyositis is a skin rash that may come before or with the muscle weakness. Other
This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.
|Medical Terms||Other Names||
|80%-99% of people have these symptoms|
|Abnormal eyelid morphology||
Abnormality of the eyelid
Abnormality of the eyelids
[ more ]
[ more ]
[ more ]
|Proximal muscle weakness||
Weakness in muscles of upper arms and upper legs
|30%-79% of people have these symptoms|
|Abnormal hair quantity||0011362|
|Abnormality of the nail||0001597|
Persistent blue color of hands, feet, or parts of face
Calcium deposits in joints
|Diffuse reticular or finely nodular infiltrations||0002207|
[ more ]
Low or weak muscle tone
[ more ]
|Recurrent respiratory infections||
Frequent respiratory infections
Multiple respiratory infections
respiratory infections, recurrent
Susceptibility to respiratory infections
[ more ]
Open skin sore
|5%-29% of people have these symptoms|
|Abnormal eosinophil morphology||0001879|
|Aplasia/Hypoplasia of the skin||
[ more ]
Bacterial infection of skin
[ more ]
Photosensitive skin rashes
Sensitivity to sunlight
[ more ]
Inability to produce voice sounds
|Feeding difficulties in infancy||0008872|
Death of body tissue due to lack of blood flow or infection
Cancer of lymphatic system
Inflammation of heart muscle
Swelling or irritation of membrane around heart
Increased blood pressure in blood vessels of lungs
|Telangiectasia of the skin||0100585|
Inflammation of blood vessel
Specialists involved in the care of someone with dermatomyositis may include:
Dermatologist Neurologist Physical therapist Orthopedist
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
American Autoimmune Related Diseases Association (AARDA)
19176 Hall Road, Suite 130
Clinton Township, MI 48038
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
- MayoClinic.com provides information about dermatomyositis. Click on the link above to access this information.
- MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
- The National Institute of Neurological Disorders and Stroke (NINDS) collects and disseminates research information related to neurological disorders. Click on the link to view information on this topic.
- The National Organization for Rare Disorders (NORD) has a report for patients and families about this condition. NORD is a patient advocacy organization for individuals with rare diseases and the organizations that serve them.
- Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Dermatomyositis. Click on the link to view a sample search on this topic.
- Sasaki H, Kohsaka H. Current diagnosis and treatment of polymyositis and dermatomyositis. Mod Rheumatol. 2018; 28(6):913-921. https://pubmed.ncbi.nlm.nih.gov/29669460.
- Chu LL, Rohekar G. Dermatomyositis. CMAJ. 2019; 191(12):E340. https://pubmed.ncbi.nlm.nih.gov/30910882.
- Bogdanov I, Kazandjieva J, Darlenski R, Tsankov N. Dermatomyositis: Current concepts. Clin Dermatol. 2018; 36(4):450-458. https://pubmed.ncbi.nlm.nih.gov/30047429.
- Sena P, Gianatti A, Gambini D. Dermatomyositis: clinicopathological correlations. G Ital Dermatol Venereol. 2018; 153(2):256-264. https://pubmed.ncbi.nlm.nih.gov/29368856.
- Lundberg IE, Tjärnlund A, Bottai M, et al. 2017 European League Against Rheumatism/American College of Rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups [published correction appears in Ann Rheum Dis. 2018 Sep;77(9):e64]. Ann Rheum Dis. 2017; 76(12):1955-1964. https://pubmed.ncbi.nlm.nih.gov/29079590.
- Strowd LC, Jorizzo JL. Review of dermatomyositis: establishing the diagnosis and treatment algorithm. Jl of Derm Treatment. 2013; 24(6):418-421. https://pubmed.ncbi.nlm.nih.gov/22686682.