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Disease Profile

Diabetic mastopathy

Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.


US Estimated

Europe Estimated

Age of onset





Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease.


Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype.


dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.


recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.


Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.


Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.


Not applicable


Other names (AKA)

Diabetic fibrous breast disease; Diabetic fibrous mastopathy; Lymphocytic mastitis;


Female Reproductive Diseases


Diabetic mastopathy are noncancerous lesions in the breast most commonly diagnosed in premenopausal women with type 1 diabetes.[1][2][3] The cause of this condition is unknown.[1][2][3][4][5] Symptoms may include hard, irregular, easily movable, discrete, painless breast mass(es).[1][4][6]


Common symptoms of diabetic mastopathy include hard, irregular, easily movable, discrete, painless breast mass(es). This condition can involve one or both breasts and can affect males and females. The breast lesions may not be palpable in some individuals. Individuals with diabetic mastopathy who have had insulin-requiring diabetes for a long time (>15 years) commonly have other diabetes complications as well (e.g., thyroid, eye, and joint involvement).[1][5][7]


The cause of diabetic mastopathy is unknown. Theories include an autoimmune reaction, genetic factors such as human leukocyte antigen (HLA) type, association with insulin therapy, and association with hyperglycemia.[1][2][5]


The diagnosis of diabetic mastopathy should be considered in patients with long-standing insulin-dependent diabetes and a firm, mobile breast mass. Initial imaging studies may include mammography and ultrasound. While these methods can help to further differentiate the mass, they cannot provide a specific diagnosis of diabetic mastopathy with confident exclusion of malignancy. A core biopsy (utilizing a needle to remove a small cylinder of tissue) is often performed for a definitive diagnosis.[8][9][7]


Typically, no treatment is necessary for diabetic mastopathy. Individuals with this condition should be advised about the condition and how to self examine the breasts to detect any changes in size and number of breast lumps. Patients should be routinely followed up with MRI or ultrasound and core biopsy if the lesions become clinically or radiologically suspicious. Lesions can be surgically removed for cosmetic reasons or if malignancy cannot be excluded.[9][7]


Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.

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    Organizations Providing General Support

      Learn more

      These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.

      In-Depth Information

      • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
      • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
      • PubMed is a searchable database of medical literature and lists journal articles that discuss Diabetic mastopathy. Click on the link to view a sample search on this topic.

        Selected Full-Text Journal Articles


          1. Keyoung JA Zuurbier CA, Tsangaris TN, Azumi N, Makariou E. Diabetic Mastopathy. Applied Radiology. 2003; https://www.medscape.com/viewarticle/462248_3.
          2. Honda M, Mori Y, Nishi T, Mizuguchi K, Ishibashi M. Diabetic mastopathy of bilateral breasts in an elderly Japanese woman with type 2 diabetes: a case report and a review of the literature in Japan. Intern Med. Epub 2007 Sep 14; https://www.jstage.jst.go.jp/article/internalmedicine/46/18/46_18_1573/_article.
          3. Sotome K, Ohnishi T, Miyoshi R, Nakamaru M, Furukawa A, Miyazaki H, Morozumi K, Tanaka Y, Iri H. An Uncommon Case of Diabetic Mastopathy in Type II Non-Insulin Dependent Diabetes Mellitus. Breast Cancer. 2006; https://www.jstage.jst.go.jp/article/jbcs/13/2/13_2_205/_article. Accessed 10/15/2009.
          4. Tsung JS, Wang TY, Lin CK. Diabetic mastopathy in type II diabetes mellitus. J Formos Med Assoc. 2005; https://www.ncbi.nlm.nih.gov/pubmed/?term=Tsung+JS%2C+Wang+TY%2C+Lin+CK.
          5. Ely KA, Tse G, Simpson JF, Clarfeld R, Page DL. Diabetic mastopathy: a clinicopathologic review. Am J Clin Pathol. 2000 Apr; https://ajcp.metapress.com/app/home/contribution.asp?referrer=parent&backto=issue,10,16;journal,96,99;linkingpublicationresults,1:300401,1.
          6. What you need to know about breast cancer. National Cancer Institute. 2005 ; https://www.cancer.gov/cancertopics/wyntk/breast/page1. Accessed 10/15/2009.
          7. Chan, CR et al. Diabetic Mastopathy. The Breast Journal. July 29, 2013; 19(5):533-538. https://www.ncbi.nlm.nih.gov/pubmed/23895671.
          8. Andrews-Tang D, Diamond AB, Rogers L, Butler D. Diabetic Mastopathy: Adjunctive Use of Ultrasound and Utility of Core Biopsy in Diagnosis. Breast J. 2000; https://www.ncbi.nlm.nih.gov/pubmed/11348362.
          9. Thorncroft K, Forsyth L, Desmond S, Audisio RA. The diagnosis and management of diabetic mastopathy.. Breast J. 2007; https://www.ncbi.nlm.nih.gov/pubmed/17983405.

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