Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.
Age of Onset
Autosomal dominant ?A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease
Autosomal recessive ?Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype
X-linked dominant ?X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
X-linked recessive ?Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder
Mitochondrial or multigenic ?Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.
Multigenic or multifactor ?Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.
Other Names (AKA)
Mucocutaneous lymph node syndrome; Kawasaki syndrome
Blood Diseases; Heart Diseases; Immune System Diseases;
?xml:namespace prefix = st1 ns = "urn:schemas-microsoft-com:office:smarttags" /
This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.
|Medical Terms||Other Names||
|80%-99% of people have these symptoms|
Swollen lymph nodes in the neck
Inflammation of the lips
High urine protein levels
Protein in urine
[ more ]
Recurrent sore throat
Inflammation of blood vessel
|30%-79% of people have these symptoms|
Pain in stomach
[ more ]
|Abnormal heart valve morphology||0001654|
|Abnormality of nail color||
Abnormality of nail colour
[ more ]
[ more ]
Inflammation of the tongue
Smooth swollen tongue
[ more ]
Elevated white blood count
High white blood count
Increased blood leukocyte number
[ more ]
Swelling or irritation of membrane around heart
|5%-29% of people have these symptoms|
|Abnormal pulmonary Interstitial morphology||
Abnormality in area between air sacs in lung
Abnormal heart rate
Heart rhythm disorders
Irregular heart beat
[ more ]
|Ascending tubular aorta aneurysm||
Bulging of wall of large artery located above heart
|Congestive heart failure||
[ more ]
|Cranial nerve paralysis||0006824|
|Double outlet right ventricle with subpulmonary ventricular septal defect without pulmonary stenosis||0011658|
Yellowing of the skin
[ more ]
Intermittent migraine headaches
[ more ]
Inflammation of heart muscle
|Nausea and vomiting||0002017|
Drooping upper eyelid
Genetic factors appear to be important to this disorder, as suggested by the increased frequency of the disease in Asian and Asian-American populations and among family members of an affected child. A number of
Other theories suggest that the disease is caused by a response from the body's
KD is not contagious; it cannot be passed from one person to another. Other
- Freeman AF, Shulman ST. Kawasaki Disease: Summary of the American Heart Association Guidelines. Am Fam Physician 2006;74:1141-50.
Related diseases are conditions that have similar signs and symptoms. A health care provider may consider these conditions in the table below when making a diagnosis. Please note that the table may not include all the possible conditions related to this disease.
Conditions with similar signs and symptoms from Orphanet
Differential diagnosis includes autoimmune and autoinflammatory diseases (e.g. systemic-onset JIA), bacterial infections (i.e. bacterial toxic shock syndrome, leptospirosis, adenophlegmon), viral infections (i.e. measles, enterovirus, Epstein-Barr virus), and toxin or drug reactions.
Visit the Orphanet disease page for more information.
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
P.O. Box 28660
Kansas City, MO 64188
American Autoimmune Related Diseases Association (AARDA)
19176 Hall Road, Suite 130
Clinton Township, MI 48038
American Heart Association
7272 Greenville Avenue
Dallas, TX 75231-4596
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
- You can obtain information on this topic from the Centers for Disease Control and Prevention (CDC). The CDC is recognized as the lead federal agency for developing and applying disease prevention and control, environmental health, and health promotion and education activities designed to improve the health of the people of the United States.
- The Centers for Disease Control and Prevention (CDC) provide more information on reporting cases of Kawasaki syndrome. Click on the CDC link to view this information.
National Center for Zoonotic, Vector-Borne, Enteric Diseases (NCZVED)
1600 Clifton Road, NE
Atlanta, GA 30329-4018
- The Vasculitis Foundation offers information on Kawasaki disease to assist patients, family members, and medical professionals in learning more about the condition.
- KidsHealth created by The Nemours Foundation's Center for Children's Health Media provides information in both English and Spanish about this condition. Click on the link to access the information page on Kawasaki disease.
- MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
- Genetics Home Reference (GHR) contains information on Kawasaki disease. This website is maintained by the National Library of Medicine.
- The National Heart, Lung, and Blood Institute (NHLBI) has information on this topic. NHLBI is part of the National Institutes of Health and supports research, training, and education for the prevention and treatment of heart, lung, and blood diseases.
- The National Organization for Rare Disorders (NORD) has a report for patients and families about this condition. NORD is a patient advocacy organization for individuals with rare diseases and the organizations that serve them.
- Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
- MeSH® (Medical Subject Headings) is a terminology tool used by the National Library of Medicine. Click on the link to view information on this topic.
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Kawasaki disease. Click on the link to view a sample search on this topic.
- Dr. Adriana Tremoulet spoke on Kawasaki Disease (KD), in her lecture "Kawasaki Disease: New Horizons" at the NIH Clinical Center in November 2016. Dr. Tremoulet is an associate professor and associate director at the Kawasaki Disease Research Center at the University of California San Diego Rady Children's Hospital. While the lecture is aimed at medical professionals, it may be of interest to anyone who seeks detailed information on KD.
- Starkebaum GA. Kawasaki disease. MedlinePlus. April 20, 2013; https://www.nlm.nih.gov/medlineplus/ency/article/000989.htm.
- Kawasaki disease. National Heart Lung and Blood Institute Web site. September 20, 2011; https://www.nhlbi.nih.gov/health/health-topics/topics/kd/.
- Sundel R. Kawasaki disease: Initial treatment and prognosis. UpToDate. 2016; https://www.uptodate.com/contents/kawasaki-disease-initial-treatment-and-prognosis.
- Kawasaki disease. Genetics Home Reference (GHR). September 2015; https://ghr.nlm.nih.gov/condition/kawasaki-disease.
- Sundel R. Kawasaki disease: Epidemiology and etiology. UpToDate. 2016; https://www.uptodate.com/contents/kawasaki-disease-epidemiology-and-etiology?source=see_link.
- What is Kawasaki disease?. American Heart Association. 2015; https://www.heart.org/idc/groups/heart-public/@wcm/@hcm/documents/downloadable/ucm_300320.pdf.