Rare Infectious Disease News

Disease Profile

Teratoma with malignant transformation

Prevalence
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.

Unknown

Age of onset

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ICD-10

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Inheritance

Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease

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Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype

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X-linked
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.

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X-linked
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder

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Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.

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Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.

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Not applicable

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Categories

Rare Cancers

Summary

A teratoma with malignant transformation (TMT) is a tumor that develops from germ cells when they grow and divide abnormally, forming a mass. Approximately 6% of teratomas develop into TMTs by a process called malignant transformation, when some of the cells in the teratoma become cancerous. TMTs can occur anywhere in the body, but most are located in the testes in men or ovaries in women. The cause of TMT is unknown. Treatment may include surgery and chemotherapy.[1]

Treatment

Because teratoma with malignant transformation (TMT) is quite rare, there are no established treatment guidelines. In general, treatment often includes surgery to remove as much of the TMT as possible. Chemotherapy that is specifically designed to target the malignant part of the TMT may also be used.[2][1]

Learn more

These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.

In-Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.

References

  1. El Mesbahi O, Terrier-Lacombe MJ, Rebischung C, Theodore C, Vanel D, Fizazi K. Chemotherapy in patients with teratoma with malignant transformation. European Urology. 2007; 51:1306-1311. https://www.ncbi.nlm.nih.gov/pubmed/17081678. Accessed 9/20/2012.
  2. Athanasiou A, Vanel D, El Mesbahi O, Theodore C, Fizazi K. Non-germ cell tumours arising in germ cell tumours (teratoma with malignant transformation) in men: CT and MR findings. European Journal of Radiology. 2009; 69:230-235. https://www.ncbi.nlm.nih.gov/pubmed/19056194. Accessed 9/20/2012.
  3. Motzer RJ, Amsterdam A, Prieto V, Sheinfeld J, Murty VV, Mazumdar M, Bosl GJ, Chaganti RS, Reuter VE. Teratoma with malignant transformation: diverse malignant histologies arising in men with germ cell tumors. Journal of Urology. 1998; 159:133-138. https://www.ncbi.nlm.nih.gov/pubmed/9400455. Accessed 9/20/2012.

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