The Rare Disease Database

The most comprehensive source of rare disease information.


Top 10 rare infectious diseases

Measured by: prevalence

Estimated US prevalenceAge of onset
Note: Incidence, not Prevalance
N/A 115,045
N/A 60,999
Lyme disease 33,666
Shigellosis 16,333
Pertussis (whooping cough) 15,609
N/A 12,474
N/A 9,025
Haemophilus influenzae, invasive 5,573
Spotted fever rickettsiosis 5,544
N/A 4,768