The Rare Disease Database

The most comprehensive source of rare disease information.


Top 10 rare infectious diseases

Measured by: prevalence

Estimated US prevalenceAge of onset
Syphilis 115,045
Salmonellosis, excluding typhoid fever 60,999
Lyme disease 33,666
Shigellosis 16,333
Pertussis (whooping cough) 15,609
Acute hepatitis A viral infection 12,474
Tuberculosis 9,025
Haemophilus influenzae, invasive 5,573
Spotted fever rickettsiosis 5,544
Acute hepatitis C viral infection 4,768