Insulin autoimmune syndrome
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.
Age of Onset
Autosomal dominant ?A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease
Autosomal recessive ?Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype
X-linked dominant ?X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
X-linked recessive ?Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder
Mitochondrial or multigenic ?Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.
Multigenic or multifactor ?Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.
Other Names (AKA)
Hirata disease; Insulin autoimmune hypoglycemia
Exactly why these antibodies against insulin are suddenly produced can vary from person to person. In some cases, insulin autoimmune syndrome occurs in a person with another
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
American Autoimmune Related Diseases Association (AARDA)
19176 Hall Road, Suite 130
Clinton Township, MI 48038
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Insulin autoimmune syndrome. Click on the link to view a sample search on this topic.
- Archambeaud-Mouveroux, F, Huc, MC, Nadalon, S, Fournier, MP, and B Canivet. Autoimmune insulin syndrome. Biomedicine & Pharmacotherapy. 1989; 43(8):581-586. https://www.ncbi.nlm.nih.gov/pubmed/2698754.
- Uchigata, Y, Eguchi, Y, Takayama-Hasumi, S, and Y Omori. Insulin autoimmune syndrome (Hirata Disease): clinical features and epidemiology in Japan. Diabetes Research and Clinical Practice. January 1994; 22(2-3):89-94. https://www.sciencedirect.com/science/article/pii/016882279490040X.
- M Funnell. Low Blood Glucose (Hypoglycemia). National Institute of Diabetes and Digestive and Kidney Diseases; August 2016; https://www.niddk.nih.gov/health-information/diabetes/preventing-diabetes-problems/low-blood-glucose-hypoglycemia.
- Bresciani, E, Bussi, A, Bazzigaluppi, E, and G Balestrieri. Insulin Autoimmune Syndrome Induced by a-Lipoic Acid in a Caucasian Woman: Case Report. Diabetes Care. September 2011; 34(9):e146-e146. https://care.diabetesjournals.org/content/34/9/e146.
- Uchigata, Y, Hirata, Y, and Y Iwamoto. Drug-induced insulin autoimmune syndrome. Diabetes Research and Clinical Practice. January 2009; 83(1):e19-20. https://www.ncbi.nlm.nih.gov/pubmed/19070385.
- Church, D, Cardoso, L, Bradbury, S, Clarke, C, Stears, A, Dover, A, Halsall, D, and R Semple. Diagnosis of insulin autoimmune syndrome using polyethylene glycol precipitation and gel filtration chromatography with ex vivo insulin exchange. Clinical Endocrinology. September 2, 2016; https://www.ncbi.nlm.nih.gov/pubmed/27588366.
- Savas-Erdeve, S, Yilmaz Agladioglu, S, Onder A, Peltek Kendirci, HN, Bas VN, Sagsak, E, Cetinkaya, S, and Aycan Z. An uncommon cause of hypoglycemia: insulin autoimmune syndrome. Hormone Research in Paediatrics. 2014; 82(4):278-282. https://www.ncbi.nlm.nih.gov/pubmed/25060673.
- Philippon, M, Sejil, S, Mugnier, M, Rocher, L, Guibergia, C, Vialettes, B, and B Delenne. Use of the continuous glucose monitoring system to treat insulin autoimmune syndrome: quantification of glucose excursions and evaluation of treatment efficacy. Diabetic Medicine: A Journal of the British Diabetic Association. July 2014; 31(7):e20-e24. https://www.ncbi.nlm.nih.gov/pubmed/25077287.